Saturday, May 29, 2021

88 more BSL-3 for China; Dr. Baric loves humanized mice

4-16-21  China will carry out major scientific research to enhance its biosecurity science and technological capacity against future infectious diseases, state-run Global Times quoted Xiang as saying.

The ministry has examined and approved the construction of three biosafety level-4 labs, or P4 labs, and 88 biosafety level-3 labs, or P3 labs, in China, he said.  https://www.business-standard.com/article/international/china-to-build-more-bio-labs-amid-questions-over-role-in-virus-origin-121041601115_1.html

……………………………………………………………………………..

59 BSL-4 that are planned, under construction or in operation around the world.  https://static1.squarespace.com/static/6048d7a0e9652c472e619f6f/t/60ae71cea2219b008f29d4ca/1622045135314/Mapping+BSL4+Labs+Globally+EMBARGOED+until+27+May+2021+1800+CET.pdf

……………………………………………………………

    Nicholson Baker, 1-4-21, writes:   I asked Jonathan A. King, a molecular biologist and biosafety advocate from MIT, whether he’d thought lab accident when he first heard about the epidemic.  “Absolutely, absolutely,” King answered.  Other scientists he knew were concerned as well.  But scientists, he said, in general were cautious about speaking out.  There were “very intense, very subtle pressures” on them not to push on issues of laboratory biohazards. Collecting lots of bat viruses, and passaging those viruses repeatedly through cell cultures, and making bat-human viral hybrids, King believes, “generates new threats and desperately needs to be reined in.”…

  “Dr. Fauci Again Dismisses Wuhan Lab As Source of Coronavirus,” said CBS News, posting a video interview of Anthony Fauci by National Geographic.  “If you look at the evolution of the virus in bats, and what’s out there now,” Fauci said, “it’s very, very strongly leaning toward ‘This could not have been artificially or deliberately manipulated’--the way the mutations have naturally evolved.”…

  this paper from 1995:  “High Recombination and Mutation Rates in Mouse Hepatitis Viruses Suggest That Coronaviruses May Be Potentially Important Emerging Viruses.”  It was written by

Dr. Ralph Baric (Wuhan 2018, 8th Intl. Symposium on Emerging Viral Diseases;  Ralph Baric attended as shown in the photo, front row)  and his bench scientist, Boyd Yount, at the University of North Carolina.  his lab was able to train a coronavirus, MHV, which causes hepatitis in mice, to jump species, so that it could reliably infect BHK (baby-hamster kidney) cell cultures.  They did it using serial passaging: repeatedly dosing a mixed solution of mouse cells and hamster cells with mouse-hepatitis virus, while each time decreasing the number of mouse cells and upping the concentration of hamster cells.  At first predictably the mouse-hepatitis virus couldn’t do much with the hamster cells, which were left almost free of infection, floating in their world of fetal-calf serum.  But by the end of the experiment, after dozens of passages through cell cultures, the virus had mutated:  it had mastered the trick of parasitizing an unfamiliar rodent.  A scourge of mice was transformed into a scourge of hamsters.  And there was more:  “It is clear that MHV can rapidly alter its species specificity and infect rats and primates,” Baric said.  “The resulting virus variants are associated with demyelinating diseases in these alternative species.”  (A demyelinating disease is a disease that damages nerve sheaths.)  With steady prodding from laboratory science, along with some rhetorical exaggeration, a lowly mouse ailment was morphed into an emergent threat that might potentially cause nerve damage in primates.  That is, nerve damage in us.

  A few years later, in a further round of “interspecies transfer” experimentation, Baric’s scientists introduced their mouse coronavirus into flasks that held a suspension of African-green-monkey cells, human cells and pig-testicle cells.  Then in 2002 they announced something even more impressive:  they’d found a way to create a full-length infectious clone of the entire mouse-hepatitis genome.  Their “infectious construct” replicated itself just like the real thing, they wrote.

  Not only that, but they’d figured out how to perform their assembly seamlessly, without any signs of human handiwork.  Nobody would know if the virus had been fabricated in a laboratory or grown in nature.  Baric called this the “no-see’m method,” and he asserted that it had “broad and largely unappreciated molecular biology applications.”   The method was named, he wrote, after a “very small biting insect that is occasionally found on North Carolina beaches.”

  In 2006 Baric, Yount and two other scientists were granted a patent for their invisible method of fabricating a full-length infectious clone using the seamless, no-see’m method.  But this time, it wasn’t a clone of the mouse-hepatitis virus — it was a clone of the entire deadly human SARS virus, the one that had emerged from Chinese bats, via civets, in 2002.   The Baric Lab came to be known by some scientists as “the Wild Wild West.”  In 2007, Baric said that we had entered “the golden age of coronavirus genetics.”  “I would be afraid to look in their freezers,” one virologist told me.  https://nymag.com/intelligencer/article/coronavirus-lab-escape-theory.html ……………………………….

5-28-21    A group of prominent scientists wrote in leading journal Nature on March 17, 2020 that 'the evidence shows that SARSCoV-2 is not a purposefully manipulated virus,' and that 'we do not believe that any type of laboratory-based scenario is plausible'.

  • In an unorthodox move, the Office of the Director of National Intelligence
  • issued a public statement on April 30 last year that 'The Intelligence
  • Community also concurs with the wide scientific consensus that the
  • COVID-19 virus was not manmade or genetically modified'


  A group of 27 scientists wrote a statement (2-19-20) in top journal The Lancet, saying they 'strongly condemn conspiracy theories suggesting that covid-19 does not have a natural origin' and 'overwhelmingly conclude that this coronavirus originated in wildlife.'  

  Three of the authors later told the Wall Street Journal that they now believe a lab accident is worth consideration as an explanation for the origins of covid-19.

  Dalgleish told DailyMail.com that he believed resistance to the theory that COVID-19 is a man-made, escaped virus comes from scientists fearful that the revelation would shut down their field.  'This looks like a weak defense to protect the discipline so that this type of genetic engineering will not be interfered with,' he said.  'I make no bones about it.  The Gain of Function engineering should have been banned ages ago.'  

NIH Director Dr. Francis Collins also told the Senate hearing that US-funded scientists at the lab 'were not approved by NIH for doing gain of function research'.  NIH ceased its funding to the EcoHealth Alliance in April 2020. https://www.dailymail.co.uk/news/article-9629563/Chinese-scientists-created-COVID-19-lab-tried-cover-tracks-new-study-claims.html

Dailymail.com from their files adds:Deputy National Security Adviser Matthew Pottinger on 1-2-21:  'There is a growing body of evidence that the lab is likely the most credible source of the virus.'

Documents obtained by The Mail on Sunday reveal that a nationwide scheme, directed by a leading state body, was launched nine years ago to discover new viruses and detect the 'dark matter' of biology involved in spreading diseases.

………………………………………………………….

  Last year, Sørensen told Norwegian broadcaster NRK that COVID-19 has properties which have 'never been detected in nature,' and that the United States has 'collaborated for many years on coronavirus research through "gain of function" studies with China.

 According to the Nankai University study (Feb. 2020), the furin binding method is "100 to 1,000 times as efficient' as SARS at entering cells.

  Israeli geneticist, Dr. Ronen Shemesh, the Furin site is the most unusual finding.  "I believe that the most important issue about the differences between ALL coronavirus types is the insertion of a Furin protease cleavage site at the Spike protein of SARS-CoV-2," he said.  "Such an insertion is very rare in evolution, the addition of such 4 Amino acids alone in the course of only 20 years is very unlikely.  There are many reasons to believe that the COVID-19 generating SARS-CoV-2 was generated in a lab.  Most probably by methods of genetic engineering," he said, adding "I believe that this is the only way an insertion like the burin protease cleavage site could have been introduced directly at the right place and become effective."

  Dr. Shemesh, who has a PhD in Genetics and Molecular Biology from the Hebrew University in Jerusalem, and over 21 years of experience in the field of drug discovery and development, said it is even “more unlikely” that this insertion happened in exactly the right place of the cleavage site of the spike protein--which is where it would need to occur to make the virus more infectious. -Daily Telegraph  "What makes it even more suspicious is that fact that this insertion not only occurred on the right place and in the right time, but also turned the cleavage site from an Serine protease cleavage site to a FURIN cleavage site," he added.

  "This protein cleaving protein is highly promiscuous, it’s found in many human tissues and cell types and is involved in many OTHER virus types activation and infection mechanisms (it is involved in HIV, Herpes, Ebola and Dengue virus mechanisms)," said Dr. Shemesh.  "If I was trying to engineer a virus strain with a higher affinity and infective potential to humans, I would do exactly that: I would add a Furin Cleavage site directly at the original less effective and more cell specific cleavage site."

  Meanwhile Flinders University Professor Nikolai Petrovsky found last year either "a remarkable coincidence or a sign of human intervention" within COVID-19 telling the Telegraph that COVID-19 is "exquisitely adapted to humans."

  Keep in mind--reporting any of this last year was punishable by social media banishment, demonetiziation, and hit-piece articles from propagandists peddling CCP talking points.  https://www.zerohedge.com/covid-19/virologists-claim-fingerprints-manipulation-prove-covid-19-man-made-no-credible-natural

………………………………………...................................................….

5-29-21  On May 20, the US House of Representatives Intelligence Committee reported “circumstantial evidence” of data that the leak of a new type of SARS-CoV-2 coronavirus originated from the Wuhan Institute of Virology.  China in turn called such a theory slander and conspiracy.  A statement from the country’s embassy in Washington noted that “some political forces have tried to manipulate and blame from the very beginning of the pandemic.”  https://thenewsglory.com/scientists-have-announced-evidence-of-laboratory-origin-of-covid-19/

……………………………………………….…

05-Apr-20     The possibility that the novel coronavirus was developed in a lab using an intermediate host, a process dubbed “serial viral passage, gets a boost from “Computational analysis suggests putative intermediate animal hosts of the SARS-CoV-2” pre-print, which finds that 2019-nCoV binds more tightly with ferret and tree shrew cells than any other species. The use of tree shrews for serial viral passage, was promoted in this 2018 paper by Yu Fan, which finds them a preferable host for laboratory serial passage, since they’re cheaper, smaller, easier to handle, and closer to humans evolutionarily and physiologically than ferrets. 

09-May-20   According to a German intelligence report, cited by Der Spiegel, Chinese President Xi Jinping asked World Health Organization (WHO) Director-General Tedros Adhanom Thebreyesu during a January 21 conversation--one week after the WHO assured the world there was “no clear evidence of human-to-human transmission”--not to reveal that the virus was in fact transmissible between humans and to delay declaring that the novel coronavirus had become a pandemic, despite the coronavirus qualifying as one by the WHO’s own former guidelines.    https://michaeltchong.com/china-disavows-the-wuhan-virus-heres-a-timeline/    ………………………………………..............................................................

No comments:

Post a Comment