https://www.independent.co.uk/voices/coronavirus-vaccine-covid-19-cure-doctor-moderna-novavax-oxford-a9523091.html
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11-25-20 In 1998 the first human trial of a DNA vaccine against human immunodeficiency virus type 1 (HIV-1) was reported (4). Since that time, DNA vaccines have been developed against a range of pathogens, including hepatitis B, influenza, Ebola and Zika viruses (reviewed in 5). However there are currently no DNA vaccines licensed for human use….
To begin with, RNA is less stable than DNA. This is one reason why mRNA vaccine formulations require specialized, cold shipping and storage conditions: the Pfizer/BioNTech vaccine will be shipped on dry ice (–80°C), while the Moderna vaccine will be shipped at a more manageable –20°C using gel packs. Upon receipt, the vaccines can be stored in a conventional refrigerator for short periods of time. Once the RNA is injected into the body, it faces another challenge. Our cells have evolved elaborate defense mechanisms intended to destroy foreign, unprotected or “naked” RNA. However the susceptibility of mRNA to degradation can be reduced by modifying the RNA during synthesis. One modification is to add in nucleoside analogs that resemble the normal nucleosides found within RNA (A, U, C and G) but have minor structural changes that make the RNA more resistant to degradation by ribonucleases. Additional structural modifications and the inclusion of regulatory sequences can also improve the stability of mRNA (6). Finally mRNA can be delivered in the form of a complex with lipid nanoparticles, which helps to stabilize the mRNA making it easier to enter the cell, and increases the amount of antigen produced per cell (7). Lipid nanoparticle formulations also elicit a stronger immune response compared to naked mRNA (8). https://www.promegaconnections.com/mrna-vaccines-for-covid-19-the-promise-and-pitfalls/
………………………………………………......................... 5-29-20 As Microsoft News peddles self-congratulatory stories about the Gates Foundation’s reorientation of its priorities to devote “‘total attention’ to the pandemic,” Dr. Fauci--making the rounds of talk shows--pledges that a vaccine will make its debut in January 2021. Not to be outdone, the White House has now unveiled “Operation Warp Speed”--a joint pharmaceutical-government-military effort aimed at “substantially shrinking the development time for a vaccine”—and President Trump promises one by the end of the year. Planet-wide COVID-19 vaccination--the overt objective that has all of these players salivating in anticipation—ignores a number of irrefutable obstacles. For one, the RNA virus being targeted, SARS-CoV-2, already “has mutated into at least 30 different genetic variants.” The variants include 19 never seen before as well as “rare changes that scientists had never imagined could happen.” Knowledge about these mutations may prove useful to clinicians wanting to better tailor their COVID-19 treatments, but the proliferation of mutations makes the chances of developing an effective vaccine immensely more uncertain. Not to worry, say the entities funded by Gates (and also the Pentagon). Scientists working in the burgeoning field of synthetic biology are confident that they can “outdo” and outsmart nature using next-generation vaccine technologies such as gene transfer and self-assembling nanoparticles—along with invasive new vaccine delivery and record-keeping mechanisms such as smartphone-readable quantum dot tattoos. Does it matter that the researchers who have been experimenting with these approaches have never been able to overcome “nasty side effects”? Apparently not. Aided and abetted by the generous Gates and military funding, high-fanfare COVID-19 vaccine planning is proceeding apace. https://www.raptureforums.com/forums/threads/high-risk-genetically-engineered-vaccines.161485
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(There are serious) concerns that are directed in particular to the following points: The formation of so-called “non-neutralizing antibodies” can lead to an exaggerated immune reaction, especially when the test person is confronted with the real, “wild” virus after vaccination. This so-called antibody-dependent amplification, ADE, has long been known from experiments with corona vaccines in cats, for example. In the course of these studies all cats that initially tolerated the vaccination well died after catching the wild virus. The vaccinations are expected to produce antibodies against spike proteins of SARS-CoV-2. However spike proteins also contain syncytin-homologous proteins, which are essential for the formation of the placenta in mammals such as humans. It must be absolutely ruled out that a vaccine against SARS-CoV-2 could trigger an immune reaction against syncytin-1, as otherwise infertility of indefinite duration could result in vaccinated women.
The mRNA vaccines from BioNTech/Pfizer contain polyethylene glycol (PEG). 70% of people develop antibodies against this substance – this means that many people can develop allergic, potentially fatal reactions to the vaccination.
The much too short duration of the study does not allow a realistic estimation of the late effects. As in the narcolepsy cases after the swine flu vaccination, millions of healthy people would be exposed to an unacceptable risk if an emergency approval were to be granted and the possibility of observing the late effects of the vaccination were to follow. https://wearethene.ws/notable/175793
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11-30-20 Big Tech and MSM platforms are silencing, cancelling, discrediting and burying search results which in any way challenge or question the mRNA Covid-19 vaccine and its methodology. Instead it’s all being highly promoted as safe, 95% effective….Vaccines are the Holy Grail for pharmaceutical companies because they are EXEMPTED from LIABILITY! (in the US but not everywhere. -r)
So lets say that tens of millions of you take this new type of mRNA vaccine. And then two years later it is discovered that something horrible begins to happen with (some or many or all) vaccinated individuals… Well, guess what… tough luck on you. This is why “normal” approval processes for vaccines and medications require LONG periods of time to establish acceptable thresholds of safety. The mRNA technique has never been used before on humans (until now).
Since the proteins will be synthesized in the host, how then will the immune system “decide” that these proteins are non-self and should be destroyed?
Is it not possible for mRNA to cause epigenetic changes to DNA? Is it not possible for such changes to trigger production of entirely unexpected cellular proteins with unpredictable long term sequelae (after effect)? What if part chains of expired mRNA are reabsorbed into the nucleus, bind back onto DNA and cause epigenetic change? That could cause oncogenesis?…
Why would we not simply boost our immune system by providing building-block nutrient minerals [to counter] viruses, bacteria and fungus [immune system long] DESIGNED to protect us? Many of these elements are missing due to bad habits, poor diet and soil degradation--[like through pesticides with their new nanotech particles that stick to things. -r]
https://modernsurvivalblog.com/pandemic/is-covid19-vaccine-safe/
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11-10-20 Vaccine makers, already shielded from liability for vaccine injuries under the National Childhood Vaccine Injury Act of 1986, will be even more protected against COVID vaccine injuries. As reported by Mercola.com, in March, the Federal Register published a “Declaration Under the Public Readiness and Emergency Preparedness Act for Medical Countermeasures Against COVID-19” which effectively sets up a new COVID “vaccine court.”
The new declaration expands the existing focus on injuries or deaths related to the recommended vaccines for children and pregnant women, to specifically include injuries stemming from a new COVID vaccine….US Gov. operation WarpSpeed has promised Pfizer $1.95 billion to deliver 100 million doses to the federal government, which will be given to Americans free of charge, the New York Times reported.
https://childrenshealthdefense.org/defender/pfizer-covid-vaccine-questions-safety/
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Germany's CureVac, a biotech with ($40 million, 2015) backing of the Bill & Melinda Gates Foundation. also backed by billionaire Dietmar Hopp, the co-founder of German software giant SAP (SAP). Hopp owns nearly half of CureVac. The German government and Big Pharma leader GlaxoSmithKline (GSK) also have big stakes.
https://www.cnn.com/2020/08/14/investing/curevac-ipo-coronavirus-vaccine-bill-melinda-gates/index.html
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11-25-20 CureVac has tagged German chemical company Wacker to churn out drug substance for its mRNA-based COVID-19 vaccine with the goal of adding 100 million doses per year to the biotech's stockpile, the partners said this week. Last week, CureVac unveiled its goal to produce 300 million doses of its vaccine, dubbed CVnCoV, in 2021 and up to 600 million doses in 2022 to meet what it expects to be greater demand
https://www.fiercepharma.com/manufacturing/curevac-ties-up-wacker-to-churn-out-more-than-100m-doses-mrna-coronavirus-vaccine
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Pfizer, Moderna, Sanofi are among big pharma manufacturing mRNA vaccines 8-6-20 mRNA vaccines will not work without an in-built delivery mechanism that enables the mRNA to shove its way into a cell’s cytoplasm. The chosen solution is to use trendy biotech “carrier systems” involving lipid nanoparticles (LNPs). LNPs “encapsulate the mRNA constructs to protect them from degradation and promote cellular uptake” and, additionally, rev up the immune system (a property that vaccine scientists tamely describe as LNPs’ “inherent adjuvant properties”). The LNP formulations in the three Covid-19 vaccines are also “PEGylated,” meaning that the vaccine nanoparticles are coated with a synthetic, nondegradable and increasingly controversial polymer called polyethylene glycol (PEG).
Moderna on its proprietary LNPs: [T]here can be no assurance that our LNPs will not have undesired effects. Our LNPs could contribute, in whole or in part, to one or more of the following: immune reactions, infusion reactions, complement reactions, opsonation reactions, antibody reactions . . . or reactions to the PEG from some lipids or PEG otherwise associated with the LNP. Certain aspects of our investigational medicines may induce immune reactions from either the mRNA or the lipid as well as adverse reactions within liver pathways or degradation of the mRNA or the LNP, any of which could lead to significant adverse events in one or more of our clinical trials. [Emphases and links added]…
The biopharma and vaccine industries appreciate PEG for its capacity to endow nanoparticles with stealth properties, which allow the particles to evade detection by the immune system and make an end run around the body’s ordinary defenses. In recent years, however PEG has come under increasing scrutiny. Investigators who once assumed that the polymer was largely “inert” are now questioning its biocompatibility and warning about PEGylated particles’ promotion of tumor growth and adverse immune responses that include “probably underdiagnosed” life-threatening anaphylaxis (also called hypersensitivity).
Unfortunately, while four out of five doctors already regularly prescribe PEGylated drugs, only one out of five are aware of the potential for anti-PEG antibody responses and only a third even know that PEG is in the drugs that they are prescribing. https://childrenshealthdefense.org/news/components-of-mrna-technology-could-lead-to-significant-adverse-events-in-one-or-more-of-our-clinical-trials-says-moderna/
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12-3-20 Russia’s Sputnik V and the vaccines produced by Sinovac and CNBG are inactivated sars-cov-2 virus https://www.china-briefing.com/news/chinas-covid-19-vaccine-development-and-availability/
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