With continuous development of foreign exchange in higher education, our university has carried out many exchange visits with foreign countries for a long time based on the foreign policy of “Go abroad and bring in foreign intelligence,” making joint efforts on exploring international exchange and cooperation programs. In recent years, the university leadership has visited the University of Oxford, Stanford University, San Francisco State University, Southern Utah University, Technical University of Munich, Teesside University, Deakin University, University of South Australia and Shizuoka University, etc. http://webcache.googleusercontent.com/search?q=cache:UnvRYasfv1UJ:https://www.mastersportal.com/universities/14571/wuhan-polytechnic-university.html&hl=en&gl=us&strip=1&vwsrc=0
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5-16-20 Munich's technical university (TUM) said Saturday a neutron reactor located at Garchingjust north of the metropole was found to have leaked nuclides into the atmosphere "slightly" above the level permitted annually in its license. http://webcache.googleusercontent.com/search?q=cache:jRke8VSLN1IJ:https://www.dw.com/en/germany-radiation-leak-detected-at-research-reactor/a-53467330&hl=en&gl=us&strip=1&vwsrc=0
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At Technical University Munich, TUM, is (in addition to a nuclear reactor project) molecular biotech, bioprocess tech, genetics, virology, medical physics, biochem and medical bioengineering research. rotating chemical reactor for use in the pharmaceuticals industry and water treatment, e.g., was start-up idea there. https://www.wzw.tum.de/index.php?id=2&L=1
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Experiments using cells cultured in the laboratory, in conjunction with artificial viruses that mimic SARS-CoV-2 as well as naturally occurring virus, indicate that neuropilin-1 is able to promote infection in the presence of ACE2. …
Additional experiments in mice showed that neuropilin-1 enables transport of tiny, virus-sized particles from the nasal mucosa to the central nervous system. When the nanoparticles were administered to the nose of the animals, they reached neurons and capillary vessels of the brain within few hours ─ in contrast to control particles without affinity for neuropilin-1. "We could determine that neuropilin-1, at least under the conditions of our experiments, promotes transport into the brain, but we cannot make any conclusion on whether this is also true for SARS-CoV-2. It is very likely that this pathway is suppressed by the immune system in most patients," says Simons. "SARS CoV-2 requires the ACE2 receptor in order to penetrate cells, but other factors such as neuropilin-1 are possibly needed in order to support its function," says Simons. "Currently, we can only speculate about the molecular processes involved. Presumably neuropilin-1 catches the virus and directs it to ACE2. Prof. Dr. Mikael Simons
Technical University of Munich
Chair of Molecular Neurobiology
phone: +49 89 4400 46495 m.simons@tum.de
http://webcache.googleusercontent.com/search?q=cache:Nv8Li3F-YB0J:https://www.tum.de/nc/en/about-tum/news/press-releases/details/36263/&hl=en&gl=us&strip=1&vwsrc=0
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Viruses often have so-called overlapping genes, which can easily be overlooked but may play an important role in virus spread, even up to the level of a pandemic. Dr. Zachary Ardern, scientist in the field of Microbial Ecology, has studied the matter in great detail. Even before the COVID 19 pandemic, we had developed a method of studying overlapping genes, “OLGenie“. This method searches genomes for patterns of genetic alterations that are unique to overlapping genes. We have now applied this as well as other methods to the wealth of new sequence data available for SARS-CoV-2.
We have identified ORF3d, a new overlapping gene in SARS-CoV-2 that has the potential to encode an unexpectedly long protein. We have found that this gene is also present in a previously discovered pangolin coronavirus, which is a relative of SARS-CoV-2. However, the new ORF3d was previously misclassified. As a result, its function was not predicted accurately. We have now described the evolution of this gene in detail, have shown that it is likely functional and have distinguished it from the various other overlapping genes currently recognized in SARS-CoV-2. In terms of genome size, SARS-CoV-2 and its many relatives are among the longest RNA viruses in existence and have a very low mutation rate. They may therefore be more susceptible to “genomic tricks” than other RNA viruses. Overlapping genes may be one of the many ways corona viruses have evolved to efficiently replicate, thwart host immunity, and transmit themselves. Knowing that there are overlapping genes and how they work may reveal new ways of controlling coronaviruses with vaccines and antiviral drugs. https://webcache.googleusercontent.com/search?q=cache:1JYmcfQJiK8J:https://www.tum.de/nc/en/about-tum/news/press-releases/details/36345/+&cd=14&hl=en&ct=clnk&gl=us
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The Institute of Virology is responsible for the diagnostics of viral diseases for our clinical partners at the university hospitals and for the education of students in medicine and biomedical sciences at TUM. Our research focuses on pathogenic human viruses such as hepatitis viruses, adeno- and noroviruses, EBV and HIV. We study molecular details of their replication cycles, and contribute to understanding host-pathogen interactions and its role in pathogenesis of viral diseases and virus-associated cancer. For this, we closely collaborate with the Institute of Virology at the Helmholtz Zentrum München and with the university hospital Klinikum Rechts der Isar. (where 2 Isar nuclear power plants have operated). https://webcache.googleusercontent.com/search?q=cache:3nyG5yTj7qwJ:https://web.med.tum.de/en/home/+&cd=4&hl=en&ct=clnk&gl=us
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10-26-20 ”Suppression of overactive inflammatory responses improves longevity and prevents age-related decline in humans. Our findings may offer potential insights to the development of new therapeutic strategies that can control and treat human infectious diseases," said Professor Wang Linfa, senior and corresponding author of the study from Duke-NUS' Emerging Infectious Diseases (EID) Programme. https://www.eurekalert.org/pub_releases/2020-10/dms-dsu102620.php
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