9-16-20 Those bat coronaviruses were originally isolated and characterized between July 2015 and February 2017 under the supervision of the Third Military Medical University (Chongqing, China) and the Research Institute for Medicine of Nanjing Command (Nanjing, China).
That critical segment of the COVID-19 virus is bounded by two “restriction sites” not found in any related bat coronaviruses, which allow researchers to easily splice, that is, cut and paste components of other viruses into the viral backbone.
The presence of those restriction sites is a known marker for genetic manipulation.
Furthermore, the COVID-19 virus contains a furin polybasic cleavage site with an amino acid sequence of proline-arginine-arginine-alanine or PRRA that facilitates membrane fusion between the virus and the human cell and widely known for its ability to enhance pathogenicity and transmissibility.
Such a sequence is not found in any other related bat coronavirus and, so far, there is no natural evolutionary pathway identified that could explain the appearance of that PRRA segment.
In contrast, techniques for the artificial insertion of such a furin polybasic cleavage site by genetic engineering have been used for over ten years.
Dr Yan and her colleagues note that the two arginine amino acids in that PRRA segment are coded by the nucleotide sequence CGG-CGG, which rarely appears in tandem and strongly suggests that this furin cleavage site is the result of genetic engineering.
In addition, the presence of a “FauI” restriction site at the furin polybasic cleavage site is also an indication of genetic manipulation.
The article concludes with a diagram describing the laboratory procedures for synthesizing the COVID-19 virus, which could have produced the virus within six months. https://www.wionews.com/opinions-blogs/chinese-scientist-says-covid-19-was-created-by-chinas-military-327862
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Emerg Microbes Infect. 2018; 7: 154.
Published online 2018 Sep 12. doi: 10.1038/s41426-018-0155-5
Genomic characterization and infectivity of a novel SARS-like coronavirus in Chinese bats
Dan Hu,1,2Changqiang Zhu,2Lele Ai,2Ting He,2Yi Wang,3Fuqiang Ye,2Lu Yang,2Chenxi Ding,2Xuhui Zhu,2Ruicheng Lv,2Jin Zhu,2Bachar Hassan,4Youjun Feng,5Weilong Tan,2 and Changjun Wang1,2
Author information Article notes Copyright and License information Disclaimer
1Department of Epidemiology, College of Preventive Medicine, Third Military Medical University, Chongqing, 400038 China
2Department of Epidemiology, Research Institute for Medicine of Nanjing Command, Nanjing, 210002 China
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Executive Editor
Department of Microbiology, Chemical and Life Science Laboratory
University of Illinois at urbana champaign, USA
Biography
2008: Post-doc research fellow, School of Molecular and Cellular Biology, University of Illinois at Urbana-Champaign
2007-2008: Post-doc associate, Institute of Microbiology, Chinese Academy of Sciences
2004-2007: Ph.D., Institute of Microbiology/Graduate School in Chinese Academy of Sciences (CAS), Beijing, China
2001-2004: M.Sc., College of Life Science, Guangxi University, Nanning, China
1997-2001: B.Sc., College of Life Sciences and Technology, Northwest University of Light Industry, Xianyang, China
Research Interest
Molecular epidemiology and pathogenesis of emerging infectious agents including Streptococcus suis, influenza virus and PRRS virus.
Molecular mechanism and genetic control of bacterial lipid metabolism, an attractive anti-microbial target. https://www.longdom.org/editor/youjun-feng-4155
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Feng, Y.
Professor at Center for Infection & Immunity, Department of Medical Microbiology & Parasitology, Zhejiang University School of Medicine, 2014 Publications (since 2005)
- Shi, Z., Xuan, C., Han, H., Cheng, X., Wang, J., Feng, Y., Srinivas, S., Lu, G. and Gao, G. F. (2014). Gluconate 5-dehydrogenase (Ga5DH) participates in Streptococcus suis cell division. Protein & cell: 1-9. https://bio-protocol.org/UserHome.aspx?id=1004276 .............................................................................................................
- Feng, Y.
Virome analysis for identification of novel mammalian viruses in bats from Southeast China
https://loop.frontiersin.org/people/402964/publications ............................................................................................................................................
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