Tuesday, August 24, 2021

the locus of events in N. Italy 2019-21

Note:  detective work involves a trail of evidence.  N. Italy, especially toward Venice on the Adriatic, is an interesting point of reference.  China has wanted to go up past there for their Belt and Road and ports linkage to eastern Euruope.  The Po valley is heavily air polluted with smog and water issues because of summer weather stagnation.  Then there's wild animal trade coming in from Balkans.  Then there's junction of certain science labs at Trieste next to Venice, the finding of very early postive for Sars2 in Trieste, etc.  This trail should be studied.  A scientist speaking Italian would be a great help to further the detective work.   -r.

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1)  Specifically, the researchers found coronavirus antibodies in 23 patients who gave samples in September and in 27 who gave samples in October.  They also found that 53.2% of these cases were participants from Lombardy.  https://www.livescience.com/coronavirus-circulating-italy-earlier-thought.html

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2)   The application of modern molecular biology to study human viral and parasitic diseases now offers unprecedented possibilities for developing more accessible diagnostics and novel strategies for effective treatment and prevention. Several Groups in Trieste, New Delhi and Cape Town are actively engaged in these areas of research.  The Molecular Virology Group in Trieste (Marcello) and the Vector Borne Group in New Delhi (Sunil) traditionally investigate the molecular characteristics of different members of the flavivirus family, including dengue, chikungunya, zika and tick-borne encephalitis viruses. 

https://www.icgeb.org/science/infectious-diseases/

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3)  Pathogenic Virus Manipulation (BL3)

Biosafety Level 3 (BL3) Laboratory at ICGEB Trieste

further information

Alessandro Marcello, Molecular Virology

Tel: +39-040-3757384

Email: marcello@icgeb.org

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4)     3-23-2019   Italian PM Giuseppe Conte and CCP chairman Xi signed deal at Rome.  Around 30 parallel deals were signed on the sidelines of the visit to Rome by Chinese President Xi Jinping, including 10 with Italian companies and others with ministries and public bodies.

  Italian Deputy Prime Minister Luigi Di Maio said the deals were worth an initial 2.5 billion euros ($2.8 billion) but had a potential value of 20 billion.  https://www.reuters.com/article/us-italy-china-deals-factbox/italy-signs-deals-worth-2-5-billion-euros-with-china-idUSKCN1R40KN

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5)    Nov. 2020    Humans are affected by more than 1,700 known pathogens:  60% of existing human infectious diseases are zoonotic and at least 75% of emerging infectious diseases of humans have an animal origin and 72% of zoonoses originate from wildlife or exotic animals.  The Bio-Crime Project was developed in 2017 by Friuli Venezia Giulia Region (Italy) and Land Carinthia (Austria) together with other public institutions to combat illegal animal trade and to reduce the risk of disease transmission from animals to humans.  Project partners agreed that a multi-agency approach was required to tackle the illegal animal trade that was high value, easy to undertake and transnational crime.  https://www.researchgate.net/publication/345307221_The_Bio-Crime_Model_of_Cross-Border_Cooperation_Among_Veterinary_Public_Health_Justice_Law_Enforcements_and_Customs_to_Tackle_the_Illegal_Animal_TradeBio-Terrorism_and_to_Prevent_the_Spread_of_Zoonoti

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6)   11-18-2020  COVID-19 was probably already circulating in Italy by September 2019, according to scientists at Milan's National Cancer Institute (INT), months before the coronavirus was first documented in the Chinese city of Wuhan.  

Gabriella Sozzi, an INT biologist, told CGTN Europe that while Italy's first coronavirus patient was officially detected on February 21 in the northern region of Lombardy, blood samples taken in September 2019 showed the presence of the antibodies against the Sars-Cov-2 virus.

"What we noticed, and it was unexpected, we found more than 10 percent of the samples presenting antibodies against the COVID-19 virus," said Sozzi.  "This finding seems to tell us that the Sars-Cov-2 virus was probably circulating at a low level in Italy before the outbreak that we had in February."

The Italian research shows that 11.6 percent of nearly 1,000 healthy volunteers taking part in the lung cancer screening trial had developed coronavirus antibodies before the disease was officially detected in Italy.In another test conducted by the University of Siena, four of the cases positive for coronavirus antibodies dated back to the first week of October, indicating the individuals were infected in September. Italian researchers announced in March there had been a higher than usual number of cases of severe pneumonia and flu reported in Lombardy at the end of 2019, another sign the coronavirus may have been circulating earlier than previously thought.

Another Italian study also reported the presence of the novel coronavirus in wastewater from Milan and Turin collected in December in 2019:  "This is further evidence that the virus was probably circulating in the autumn."  https://newseu.cgtn.com/news/2020-11-17/COVID-19-was-spreading-in-Italy-by-September-2019-study-indicates-VuSqUttP8s/index.html

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7)  11-11-2020    In the first 2 months, September–October 2019, 23/162 (14.2%) patients in September and 27/166 (16.3%) in October displayed IgG or IgM antibodies, or both.  The first positive sample (IgM-positive) was recorded on September 3 in the Veneto region, followed by a case in Emilia Romagna (September 4), a case in Liguria (September 5), two cases in Lombardy (Milano Province; September 9), and one in Lazio (Roma; September 11).  By the end of September, 13 of the 23 (56.5%) positive samples were recorded in Lombardy, three in Veneto, two in Piedmont, and one each in Emilia Romagna, Liguria, Lazio, Campania and Friuli.  

-Dr. Giovanni Apolone, team-leader, Fondazione IRCCS Istituto Nazionale Tumori, Milan, Italy   https://journals.sagepub.com/doi/10.1177/0300891620974755

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8)   3-10-21  Graphene nanoparticles and their influence on neurons   (Nanowerk News)  Effective, specific, with a reversible and non-harmful action:  the identikit of the perfect biomaterial seems to correspond to graphene flakes, the subject of a new study carried out by SISSA - International School for Advanced Studies of Trieste, (with other teams)…This nanomaterial (graphene) has demonstrated the ability to interact with the functions of the nervous system in vertebrates in a very specific manner  https://www.nanowerk.com/nanotechnology-news2/newsid=57490.php

(But we know otherwise; graphene nanoparticles will destroy brain cells.  -r) 

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9)   The Course

The International School for Advanced Studies (SISSA), the International Center for Genetic Engineering Biotechnology (ICGEB), the University of Trieste and the University of Udine offer a new Joint PhD Program in Molecular Biology (JuMBO).

Admission Exam 2018 and PhD Program

Important dates for the admission to the PhD Program 2018.

JuMBO is composed by two activities: Theoretical Introduction to Molecular
Biology and Carrying on the experimental project subject of Thesis. 

Course Program 2018-2019


PhD Programs Functional and Structural Genomics and JUMBO First Year Courses – May/June 2019: Bioinformatic data analysis

Faculty


Prof. Carlo Vascotto

Assistant Professor

University of Udine

Laboratory of Molecular Oncology

carlo.vascotto@uniud.it


Prof. Giuseppe Legname

Full Professor

SISSA

PhD program coordinator

Prion Biology Laboratory

legname@sissa.it


Dr. Federica Benvenuti

Group Leader

ICGEB

Cellular Immunology

benvenut@icgeb.org


Prof. Emanuele De Paoli

Assistant Professor

University of Udine

Laboratory of Plant Genomics

emanuele.depaoli@uniud.it


Prof. Fiamma Mantovani

Assistant Professor

University of Trieste

Molecular Oncology Unit, LNCIB Trieste

fiamma.mantovani@lncib.it      

https://phdjumbo.sissa.it/

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10)

                 Giuseppe Legname earned his Doctor of Philosophy at the University of Warwick, UK.  After a long spell in industry in the field of immunotherapy, he moved to the National Institute for Medical Research (NIMR), Medical Research Council in London, UK as a Research Associate.  In 1999 he became Assistant Adjunct Professor, and later Associate Adjunct Professor, at the Institute for Neurodegenerative Diseases (IND), University of California at San Francisco, USA, under the direction of 1997 Nobel Laureate Professor Stanley B. Prusiner.  Since then he has been involved in basic research projects in the field of Prion Biology and Disease.  In 2006 he joined the faculty of SISSA in Trieste as Associate Professor at the Department of Neuroscience.  Currently he is the Coordinator of the PhD Program in Functional and Structural Genomics at SISSA and member-elect of the Academic Senate.  He is a reviewer for several International journals, academic editor for PLoS ONE and co-author of various patents.  The main focus of his research program is the physiological function of the prion protein in mammals and the mechanisms of prion replication as well as the structural characterization of molecular determinants for prion infectivity.   https://phdjumbo.sissa.it/faculty/prof-giuseppe-legname

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