first sample tested positive for SARS-CoV-2 RNA was a urine sample collected September 12th, 2019, from 8-months old child, Lombardy

 8-6-2021    TITLE: Molecular evidence for SARS-CoV-2 in samples collected from patients with 3 morbilliform eruptions since late summer 2019 in Lombardy, Northern Italy

the very first sample that tested positive for SARS-CoV-2 RNA was a urine sample collected September 12th, 2019, from an 8-months old child whose serum was also IgG and IgM 213 positive (Table 2).

234 None of the positive patients reported any history of travel in the prior two weeks the onset of rash. 235  

The first pre-pandemic cases were mainly localized East of Milan and Brescia (September236 October, 2019)….263 Since all three β mutations were already detected by October 22, 2019, we project that the 264 progenitor of SARS-CoV-2 already existed 11·6 – 16·2 weeks earlier than October 22, i.e., in late 265 June 2019 to late August 2019, using a simple extrapolation based on six mutations and the current 266 range of mutation rate estimates.  (footnote: Pekar J, Worobey M, Moshiri N, Scheffler K, Wertheim JO. Timing the SARS-CoV-2 index 444 case in Hubei province. Science 2021; 372: 412–7.)   

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