Dr. Jane Ruby on spions, magnetofection: https://rumble.com/vi6vfp-exposed-magnetism-intentionally-added-to-vaccine-to-force-mrna-through-enti.html
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pubmed.ncbi.nlm.nih.gov › 24715289Superparamagnetic nanoparticle delivery of DNA vaccine
The efficiency of delivery of DNA vaccines is often relatively low compared to protein vaccines. The use of superparamagnetic iron oxide nanoparticles (SPIONs) to deliver genes via magnetofection shows promise in improving the efficiency of gene delivery both in vitro and in vivo.
◦ Author: Fatin Muhammed Nawwab Al-Deen, Cordelia Selomulya, Charles Wai Chung Ma, Ross Leon Coppel
◦ Publish Year: 2014
◦ Author: Fatin Muhammed Nawwab Al-Deen, Cordelia Selomulya, Charles Wai Chung Ma, Ross Leon Coppel
◦ Publish Year: 2014
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Superparamagnetic nanoparticle (spion) delivery of DNA vaccine
Fatin Nawwab Al-Deen 1 , Cordelia Selomulya, Charles Ma, Ross L Coppel
Affiliations
• PMID: 24715289
• DOI: 10.1007/978-1-4939-0410-5_12
Abstract
The efficiency of delivery of DNA vaccines is often relatively low compared to protein vaccines. The use of superparamagnetic iron oxide nanoparticles (SPIONs) to deliver genes via magnetofection shows promise in improving the efficiency of gene delivery both in vitro and in vivo. In particular, the duration for gene transfection especially for in vitro application can be significantly reduced by magnetofection compared to the time required to achieve high gene transfection with standard protocols. SPIONs that have been rendered stable in physiological conditions can be used as both therapeutic and diagnostic agents due to their unique magnetic characteristics. Valuable features of iron oxide nanoparticles in bioapplications include a tight control over their size distribution, magnetic properties of these particles, and the ability to carry particular biomolecules to specific targets. The internalization and half-life of the particles within the body depend upon the method of synthesis. Numerous synthesis methods have been used to produce magnetic nanoparticles for bioapplications with different sizes and surface charges. The most common method for synthesizing nanometer-sized magnetite Fe3O4 particles in solution is by chemical coprecipitation of iron salts. The coprecipitation method is an effective technique for preparing a stable aqueous dispersions of iron oxide nanoparticles. We describe the production of Fe3O4-based SPIONs with high magnetization values (70 emu/g) under 15 kOe of the applied magnetic field at room temperature, with 0.01 emu/g remanence via a coprecipitation method https://pubmed.ncbi.nlm.nih.gov/24715289/
Fatin Nawwab Al-Deen 1 , Cordelia Selomulya, Charles Ma, Ross L Coppel
Affiliations
• PMID: 24715289
• DOI: 10.1007/978-1-4939-0410-5_12
Abstract
The efficiency of delivery of DNA vaccines is often relatively low compared to protein vaccines. The use of superparamagnetic iron oxide nanoparticles (SPIONs) to deliver genes via magnetofection shows promise in improving the efficiency of gene delivery both in vitro and in vivo. In particular, the duration for gene transfection especially for in vitro application can be significantly reduced by magnetofection compared to the time required to achieve high gene transfection with standard protocols. SPIONs that have been rendered stable in physiological conditions can be used as both therapeutic and diagnostic agents due to their unique magnetic characteristics. Valuable features of iron oxide nanoparticles in bioapplications include a tight control over their size distribution, magnetic properties of these particles, and the ability to carry particular biomolecules to specific targets. The internalization and half-life of the particles within the body depend upon the method of synthesis. Numerous synthesis methods have been used to produce magnetic nanoparticles for bioapplications with different sizes and surface charges. The most common method for synthesizing nanometer-sized magnetite Fe3O4 particles in solution is by chemical coprecipitation of iron salts. The coprecipitation method is an effective technique for preparing a stable aqueous dispersions of iron oxide nanoparticles. We describe the production of Fe3O4-based SPIONs with high magnetization values (70 emu/g) under 15 kOe of the applied magnetic field at room temperature, with 0.01 emu/g remanence via a coprecipitation method https://pubmed.ncbi.nlm.nih.gov/24715289/
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This is only for the very tough-- 
https://www.youtube.com/watch?v=is6Dtx8bXSU
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