Monday, May 4, 2020

“A human monoclonal antibody blocking SARS-VoV-2 Infection.”

May 4, ‘20     researchers report discovery of antibody that blocks infection by SARS-CoV-2 in cells    https://www.uu.nl/en/news/researchers-report-discovery-of-antibody-that-blocks-infection-by-the-novel-coronavirus-sars-cov-2
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May 4  The paper is titled “A human monoclonal antibody blocking SARS-VoV-2 Infection.”  In addition to Drs. Bosch and Grosveld, authors on the paper included:  Chunyan Wang, Wentao Li and Frank van Kuppeveld of Utrecht University; Nisreen Okba and Bart Haagmans of Erasmus Medical Center (Rotterdam); Dubravka Drabek and Rien van Haperen of Erasmus Medical Center and Harbour Antibodies; and Albert Osterhaus of the University of Veterinary Medicine (Hannover, Germany).
https://www.dutchnews.nl/news/businesswire/utrecht-university-erasmus-medical-center-and-harbour-biomed-researchers-report-discovery-of-antibody-that-blocks-novel-coronavirus-sars-cov-2-infection-in-cells/
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3-14-20   In other words a first-ever antibody to the coronavirus. Professor of cell biology Frank Grosveld (71) keeps his cool: “I am too old to jump on a table.  We have published an article about an antibody that we had already isolated before the current pandemic and which cross-reacted (biological term for repelling a foreign substance, ed.) with various coronaviruses. The antibody prevents the virus from being able to infect and can also help in the detection of the virus.”
How did you discover that?
  “About fifteen years ago I started a hobby project to see if we could make human antibodies (proteins made in response to antigens such as viruses, ed.) in mice. That succeeded and eventually led to the establishment of an Erasmus MC company: Harbor Antibodies BV. We now have branches in Shanghai, Boston and Rotterdam where the innovation branch is located. They mainly develop antibodies to cure tumors.”  https://www.erasmusmagazine.nl/en/2020/03/14/unique-discovery-in-erasmus-mc-antibody-against-corona/
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Franklin Gerardus Grosveld, FRS (born 18 August 1948)[2] is a Dutch molecular biologist whose research interests are in the regulation of transcription during development with a particular emphasis on mammalian erythroiddifferentiation.  He is a professor and Head of the Department of Cell Biology at the Erasmus MC, Rotterdam.  He obtained his PhD degree from McGill University, Montreal and after completing two postdoctoral periods with Charles Weissmann (Zurich) and Richard Flavell(Amsterdam and London) he started his own research group at the National Institute for Medical Research, Mill Hill.

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